Connect with us

News

Is Jane Espenson Married to her Partner? Who’s her Husband? Net Worth

Published

on


Jane Espenson Jane Espenson is an American television writer and producer. Espenson has worked on both situation comedies and serial dramas. She had a five-year stint as a writer and producer on Buffy the Vampire Slayer and shared a Hugo Award with Drew Goddard for her writing on the episode “Conversations with Dead People

What is the Jane Espenson?

Jane Espenson came into this beautiful world on July 14, 1964. She was born in Ames, Iowa, in the United States of America. By birth her sun sign is cancer. As of now, she is 57 years old. By nationality, she holds American citizenship and is of white background. Similarly, she follows the Christianity religion.

Caption: Jane Espenson  a frame ( Photo: once upon time.fandom.)

There is no such information regarding her parents. She was born in a well-maintained family. Her parents raised her and her siblings with lots of love and care. She spent her childhood days in a loving and friendly environment.

Education of Jane Espenson

Regarding her educational field, she seems to be an educated ad qualified person. She completed her schooling at Ames High School. After completing high school, she went to the University of California, Berkeley, for her higher education. she gets a bachelor degree in Linguistic

What is the Net Worth of Jane Espenson?

Jane Espenson is successful in collecting a handsome sum of money from his professional career. According to the celebrity’s net worth, she has an estimated net worth of $1.9 million. She also collects a good sum of money from the ads and sponsors as well. She is a wealthy writer and tv personality

Caption: Jane Espenson photo on award show  ( Photo: Fandamopolis.)

Jane is able to collect this decent sum of fortune from her successful long-term career as an American television writer, and photographer as well. From her career, she has gained a name along with the good fortune of money. As of now, she is living a happy and luxurious life with her family from the money she gains

How tall is Jane Espenson?

Jane Espenson is a beautiful lady with a dashing personality. She is both physically and mentally fine. Also, She has got an hourglass body figure. She stands at a good height of 5feet 2inche or 1.62 meters tall.

Similarly, her total body weight according to her height is around 58 kg or 128 lbs. However, her total body measurement is not mentioned on the internet sources. She has got a beautiful pair of brown color eyes with long dark brown color hair. She wears a shoe size of 6US.

Who is the Husband of Jane Espenson?

Jane Espenson is currently single. She is secretive regarding her personal life. So, she kept her private life far from the media’s insight. Similarly, her information on the internet is the least.

Caption: Jane Espenson o a frame ( Photo: IMDB.)

Likewise, she is happily living her life. Also, she also donates her money as a donation fund. She is not involved in any kind of controversies and rumors

Caarer of Jane Espenson

  • Jane submitted several spec scripts for Star Trek: The Next Generation as part of a script submission program open to amateur writers; Espenson has referred to the program as the “last open door of show business.”
Caption:  Writer Jane Espenson arrives at the 2012 Writers Guild Awards at the Hollywood Palladium (Photo by Alberto E. Rodriguez/Getty Images for WGAw)
  • In 1995 she wrote the episode “The Age of Reason” for the short-lived situation comedy Me and the Boys.
  • Also, In 2011, she is working as a freelancer, Espenson wrote episode 6 of season 1 of Game of Thrones, titled “A Golden Crown.” It is notable as one of only four Game of Thrones episodes written by her
  • Jane has won the Writers Guild of America Award for Original Short Form – New Media in 2014.

News

Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in Households with Children, Southwest Germany, May–August 2020 – The Maravi Post

Published

on

By


Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.

Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in Households with Children, Southwest Germany, May–August 2020

Maximilian Stich1, Roland Elling1, Hanna Renk1, Aleš Janda1, Sven F. Garbade, Barbara Müller, Hans-Georg Kräusslich, Dorit Fabricius, Maria Zernickel, Peter Meissner, Daniela Huzly, Jürgen Grulich-Henn, Anneke Haddad, Tessa Görne, Benedikt Spielberger, Linus Fritsch, Alexandra Nieters, Hartmut Hengel, Andrea N. Dietz, Thomas Stamminger, Tina Ganzenmueller, Natalia Ruetalo, Andreas Peter, Jonathan Remppis, Thomas Iftner, Kathrin Jeltsch, Tim Waterboer, Axel R. Franz, Georg Friedrich Hoffmann, Corinna Engel2, Klaus-Michael Debatin2, Burkhard Tönshoff2Comments to Author , and Philipp Henneke2

Author affiliations: Heidelberg University Hospital, Heidelberg, Germany (M. Stich, S.F. Garbade, B. Müller, H.-G. Kräusslich, J. Grulich-Henn, K. Jeltsch, G.F. Hoffmann, B. Tönshoff); University Medical Centre and Faculty of Medicine Freiburg, Freiburg, Germany (R. Elling, D. Huzly, A. Haddad, T. Görne, B. Spielberger, L. Fritsch, A. Nieters, H. Hengel, P. Henneke); University Hospital and Faculty of Medicine Tübingen, Tübingen, Germany (H. Renk, T. Ganzenmueller, N. Ruetalo, A. Peter, J. Remppis, T. Iftner, A.R. Franz, C. Engel); Ulm University Medical Center, Ulm, Germany (A. Janda, D. Fabricius, M. Zernickel, P. Meissner, A.N. Dietz, T. Stamminger, K.-M. Debatin); German Cancer Research Center (DKFZ), Heidelberg (T. Waterboer)

Suggested citation for this article

Abstract

Resolving the role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in households with members from different generations is crucial for containing the current pandemic. We conducted a large-scale, multicenter, cross-sectional seroepidemiologic household transmission study in southwest Germany during May 11–August 1, 2020. We included 1,625 study participants from 405 households that each had ≥1 child and 1 reverse transcription PCR–confirmed SARS-CoV-2–infected index case-patient. The overall secondary attack rate was 31.6% and was significantly higher in exposed adults (37.5%) than in children (24.6%–29.2%; p = <0.015); the rate was also significantly higher when the index case-patient was >60 years of age (72.9%; p = 0.039). Other risk factors for infectiousness of the index case-patient were SARS-CoV-2–seropositivity (odds ratio [OR] 27.8, 95% CI 8.26–93.5), fever (OR 1.93, 95% CI 1.14–3.31), and cough (OR 2.07, 95% CI 1.21–3.53). Secondary infections in household contacts generate a substantial disease burden.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread globally since its emergence in December 2019. As of March 2021, >120 million infections have been reported, and >2.7 million deaths have been attributed to the novel coronavirus disease (COVID-19) (1). The severity of COVID-19 and the risk for a complicated course of illness or death increase with age (2,3). In terms of SARS-CoV-2 transmission, conjectures early in the pandemic were that asymptomatic (i.e., healthy) but infectious children played a particularly substantial role. The underlying assumption that children were drivers of the pandemic was based on experience with seasonal influenza virus. Consequently, closures of schools and preschools were among the earliest nonpharmaceutical interventions for transmission (4). However, the role of children in the transmission of SARS-CoV-2 remains controversial (57).

Next to superspreading events (8), intrahousehold transmission of SARS-CoV-2 is a major driver of the pandemic (9). A recent systematic review and meta-analysis based on reverse transcription PCR (RT-PCR) testing of SARS-CoV-2 RNA from nasopharyngeal or oropharyngeal swab specimens calculated a secondary attack rate (SAR) of 16.6% in households (10). In individual studies, the SAR in children varied from 4% (11) to 36% (12); hence, the data vary widely. Only a minority of studies reported separate SARs from pediatric index cases, and children accounted for <10% of index cases when reported (8,9,13,14).

Low detection rates of SARS-CoV-2 RNA by RT-PCR in children might not precisely reflect the frequency of infections. Mild or even asymptomatic disease in children combined with higher rates of aversion and incorrect swab collection might lead to underestimation of the infection risk, especially in symptom-based transmission studies. Determining the presence of SARS-CoV-2 antibodies could overcome some of these limitations (15). In a cross-sectional investigation of 2,482 child–parent pairs without known prior SARS-CoV-2 infection, we found a 3-fold lower SARS-CoV-2 seroprevalence in children than in their parents (16). Previous household transmission studies found SARS-CoV-2–specific IgG in 28% (17), 34% (18), 42% (19), 45% (20) and 52% (21) of exposed children; SARs were lower (18), similar to (17,21), or higher (19) than in exposed adult household members. However, the low number of studied households with children (21–130 households) (1721) was a limitation.

We performed a large-scale multicenter seroepidemiologic study on transmission of SARS-CoV-2 in households with >1 child. Our objectives were to determine the SARS-CoV-2 seroprevalence and SAR in children compared with adults from the same households and, second, to identify risk factors associated with infectiousness of index case-patients and susceptibility of contacts.

Methods

Study Design and Conduct

We conducted a multicenter, cross-sectional SARS-CoV-2 transmission study on the prevalence of SARS-CoV-2 antibodies in members of households with 1 index case-patient with a previous SARS-CoV-2 infection confirmed by RT-PCR from a nasopharyngeal or oropharyngeal swab specimen. Households that met the eligibility criteria were invited to participate through the local health authorities Alb-Donau, Breisgau-Hochschwarzwald, Heidelberg/Rhein-Neckar, Karlsruhe, Mannheim, Neckar-Odenwald, Reutlingen, and Tübingen in the Federal State of Baden-Württemberg, Germany. We enrolled participants at the University Children’s Hospitals in Freiburg, Heidelberg, Tübingen, and Ulm during May 11– August 1, 2020. At time of study enrollment, we collected blood samples from participants for antibody measurement and retrospectively determined symptom and infection history through a questionnaire and serologic tests. The study was designed, analyzed, and reported according to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guidelines (https://www.strobe-statement.org).

Ethics

The study protocol was approved by the independent ethics committees of the Medical Faculty Heidelberg (approval no. S-294/2020), Medical Faculty Tübingen (approval no. 293/2020BO2), University of Ulm (approval no. 152/20), and University of Freiburg (approval no. 256/20_201553). The study was conducted according to the Declaration of Helsinki. Written informed consent was obtained from all household members and parents or guardians; children gave consent when appropriate for their age.

Eligibility Criteria and Study Procedure

Households were eligible for enrollment if they met all of these inclusion criteria: SARS-CoV-2 detection by RT-PCR from a nasopharyngeal or oropharyngeal swab specimen in >1 household member, >1 household member <18 years of age, residency in the state of Baden-Württemberg, and all household members having been officially released from quarantine. Key exclusion criteria were lack of written consent and insufficient knowledge of the German language.

Questionnaire items were number of household members and, for each member, age, sex, and whether they had ever tested positive for SARS-CoV-2. We asked participants reporting an RT-PCR-confirmed SARS-CoV-2 infection for the date when the positive specimen was collected, COVID-19–related symptoms (fever, cough, diarrhea, or dysgeusia), and whether they were hospitalized for COVID-19. We defined the index case-patient as the household member with the first SARS-CoV-2 RNA–positive specimen collected. We validated this definition in a subset of 54 households from 1 study center for which additional questionnaire information on transmission routes from nonhousehold contacts with COVID-19 were available. In 52 (96.3%) of 54 households, the definition of the index case based on timing of the RT-PCR test was consistent with the definition based on this anamnestic information. The RT-PCR test was performed within 24 hours, and a positive test result immediately triggered a strict home isolation and quarantine for all household members for >14 days unless hospitalization was required.

Laboratory Analysis

We sent blood samples to the respective diagnostic laboratories in the 4 study centers, and serum was prepared on the same day. Samples were either immediately analyzed or stored at 4°C until further processing. Samples were analyzed for IgG reactive to the S1 domain of the viral spike glycoprotein and the SARS-CoV-2 nucleocapsid (N) protein. Antibodies reactive to the N protein were measured either with the Elecsys Anti-SARS-CoV-2 IgG/IgM ECLIA test kit (Roche, https://www.roche.com) processed on a Roche Cobas e601 or e411 module (in Heidelberg, Tübingen, and Ulm), or by recomWell SARS-CoV-2 IgG ELISA (Mikrogen Diagnostik, https://www.mikrogen.de/start.html) run on a BEP III analyzer in (Freiburg). SARS-CoV-2 IgG for the S1 domain of the spike protein were measured with the Euroimmun Anti-SARS-CoV-2-ELISA (IgG) test kit (Euroimmun, https://www.euroimmun.com) in Freiburg and Ulm. In Heidelberg and Tübingen, IgG/IgM directed against the receptor-binding domain of S1 were analyzed with the SARS-CoV-2 Total (COV2T) CLIA Assay (Siemens Healthineers, https://www.siemens-healthineers.com) on a Siemens ADVIA Centaur XP analyzer.

We categorized serum samples with concordant results in both assays as seropositive or seronegative. In case of discordant results, we performed additional, study site–specific measurements. These measurements were a neutralization assay (Tübingen) (22); the Euroimmun Anti-SARS-CoV-2-ELISA (IgG) (Euroimmun) (Heidelberg); the Elecsys Anti-SARS-CoV-2 IgG/IgM ECLIA (Roche) (Freiburg); or the ARCHITECT SARS-CoV-2 IgG, a test for IgG against the viral N protein (Abbott Laboratories, https://www.abbott.com) on an Abbott ARCHITECT 1000 instrument (Ulm). We classified serum samples with a positive reaction in the additional assay as seropositive.

Statistical Analysis

We performed analyses with R version 4.0.0 (R Foundation for Statistical Computing, https://www.r-project.org). We present results for continuous variables as mean with SD (for data with normal distribution) or median with interquartile ranges (IQR) and minimum and maximum values, unless stated otherwise. SARS-CoV-2 seropositivity served as a proxy for previous infection. We calculated the observed SAR by dividing the number of exposed SARS-CoV-2 IgG-positive household members by all exposed household members. To model and predict SAR, we used generalized linear mixed-effects logistic regression models (GLMM) with a logit function and the dependent variable “SARS-CoV-2 infection (yes/no)” of exposed household members and the predictors age of index case-patient, age of exposed household member, sex of index case-patient, sex of exposed household member, household size, and SARS-CoV-2–seropositivity in the index case.

We used a generalized linear mixed-effects model tree (23) to detect subgroup interactions in SAR of exposed household members (R package glmertree). This method uses model-based recursive partitioning to detect subgroup interactions and a GLMM to estimate the random-effects parameters (23). No a priori formulated hypotheses were tested, and therefore all p values and CIs are reported as descriptive measures. We compiled a more detailed description of GLMM models, simulations, violin plots, and R code (Appendix)

Results

Study Population

Figure 1

Flowchart of participant enrollment in study of transmission of severe acute respiratory syndrome coronavirus 2 in households with children, southwest Germany, May–August 2020. RT-PCR, reverse transcription PCR; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

Figure 1. Flowchart of participant enrollment in study of transmission of severe acute respiratory syndrome coronavirus 2 in households with children, southwest Germany, May–August 2020. RT-PCR, reverse transcription PCR; SARS-CoV-2, severe acute…

We enrolled 473 households during May 11–August 1, 2020 (Appendix Figure). We excluded households in which the index case could not be determined (n = 61). SARS-CoV-2–seropositivity plateaued at ≈30 days after a positive RT-PCR test for SARS-CoV-2 RNA (Appendix Table 1). To reduce the probability of negative serologic results because of imminent seroconversion, we excluded households that participated <30 days after a positive RT-PCR test of the index case (n = 7). A total of 405 households with 1,625 members (922 adults and 703 children) were available for final analysis (Table 1; Figure 1). The median age of index case-patients (n = 405) was 43.6 (range 1.36–71.5) years; 25 index case-patients (6.2%) were children. Among exposed household members (n = 1,220), 678 participants (55.6%) were children and 542 (44.4%) were adults. The sex distribution of index case-patients and exposed household members was balanced (Table 1).

SARS-CoV-2 Seropositivity and Observed Secondary Attack Rates

A total of 400 of 1,220 exposed household members tested positive for SARS-CoV-2 IgG and were categorized as previously infected (Figure 1), resulting in an overall observed SAR of 32.8%. Among the 405 index case-patients with RT-PCR–confirmed SARS-CoV-2 infection, 363 (89.6%) were seropositive and 42 (10.4%) were seronegative at the time of study participation. The rate of seropositivity in households with a seropositive index case-patient (393 of 1,090 [36.1%]) was 6-fold higher than the rate in households with a seronegative index case-patient (7 of 130 [5.4%]) (Table 2). The observed SAR in adults was 38.0% (206 of 542) compared with 28.6% (194 of 678) in children; it did not differ substantially among the 3 pediatric age groups (<6 years, 26.6%; 6–11.9 years, 30.7%; 12.0–17.9 years, 27.9%).

The observed SAR in exposed household members increased with the age of the index case-patient, from 13.3% for those <12 years of age to 71.4% for those >60 years of age (Table 2). The observed SAR in exposed male (32.5%) and female (33.1%) household members and in those with a male (33.9%) or female (31.6%) index case-patient were similar. Among the 405 index case-patients, 394 (97.3%) reported COVID-19–related symptoms and 9 (2.2%) were asymptomatic; no data were reported for 2 index case-patients. The most prevalent symptom was dysgeusia; cough, fever, and diarrhea were next most prevalent (Appendix Table 2). Overall symptoms (98.3% vs. 88.1%), and especially fever (58.4% vs. 33.3%) and dysgeusia (66.1% vs. 31.0%), were more prevalent in seropositive index case-patients than in seronegative index case-patients. A total of 22 (5.4%) index case-patients were hospitalized.

Risk Factors for SARS-CoV-2 Transmission

We used a linear mixed-effects logistic regression model to analyze these risk factors for virus transmission: age and sex of index case-patients and of exposed household members, household size, and SARS-CoV-2 seropositivity of the index case-patient (Table 2). SARS-CoV-2 seropositivity of the index case-patient was the risk factor most strongly associated with the SAR (odds ratio [OR] 27.8, 95% CI 8.26–93.5; p<0.001).

The predicted SAR in adults was higher than the predicted SARs in the 3 pediatric age groups, which were broadly similar (Table 2). Age of the index case-patient was also a risk factor for virus transmission. The predicted SAR in exposed household members was lowest when the index case-patient was <12 years of age (12.0%) and highest with an index case-patient >60 years of age (72.9%) and plateaued around 31% for index case-patients 12.0–59.9 years of age. It differed significantly between adults 18.0–59.9 years of age and those >60 years of age (OR 9.02, 95% CI 1.19–72.8; p = 0.039). Sex of the index case-patient and sex of the exposed household member were not associated with the SAR (Table 2). Larger households tended toward lower predicted SARs (Table 2); when we applied a Fisher exact test to the observed data, households with >4 household members were associated with a lower SAR (Appendix Table 3).

Figure 2

Observed and predicted SARs in household members exposed to severe acute respiratory syndrome coronavirus 2, southwest Germany, May–August 2020. SARs shown are associated with age of index case-patient (A), age of exposed household member (B), household size (C), and SARS-CoV-2 seropositivity of the index case-patient (D). The mean observed SAR is shown as a black dot. The mean (black triangles), interquartile range (white bars), maximum and minimum (ends of vertical black line), and distribution (gray shading) of the predicted SAR are shown in the violin plots. The predicted SARs were calculated from the generalized linear mixed-effects logistic regression model. SAR, secondary attack rate.

Figure 2. Observed and predicted SARs in household members exposed to severe acute respiratory syndrome coronavirus 2, southwest Germany, May–August 2020. SARs shown are associated with age of index case-patient (A), age…

We compared the observed and predicted SAR associated with age of the index case-patient, age of exposed household members, household size, and SARS-CoV-2 seropositivity of the index case-patient (Figure 2). We calculated the predicted SAR by using the generalized mixed-effects logistic regression model with simulations. In all 4 analyses, the observed and predicted SARs were almost identical, indicating that this logistic regression model was valid.

Figure 3

Figure 3. Generalized linear mixed model binary decision trees in study of transmission of severe acute respiratory syndrome coronavirus 2 in households with children, southwest Germany, May–August 2020. A) Model incorporating the…

We used the same risk factors for a generalized linear mixed model binary decision tree to study subgroup interactions of risk factors for SAR. The most dominant risk factor for transmission was SARS-CoV-2-seropositivity of the index case-patient; the next most dominant risk factor was increased age of exposed household members (Figure 3, panel A). In an alternative generalized linear mixed model binary decision tree, only age of the index case-patient was considered a risk factor, and the age of exposed household members was fixed in each terminal node (Figure 3, panel B). In this model, the SAR increased with age of the index case-patient. Within each age group of index case-patient, the SAR also increased with age of the exposed household member (Figure 3, panel B). The observed SAR was 23.1% (80/346) if the index case-patient was <37.8 years of age, 34.7% (287/827) if the index case-patient was 37.8–57.9 years of age, and 70.2% (33/47) if the index case-patient was >57.9 years of age. However, cutoff values determined by generalized linear mixed-effects model trees are data-driven and should not be interpreted as fixed parameters. When we excluded the 42 households with a seronegative index case-patient and analyzed the remaining 363 households (Appendix Table 4) or included the time interval from positive SARS-CoV-2 RNA specimen collection in the index case-patient to the serologic assessment of the household (Appendix Table 5), we obtained comparable results.

We analyzed the COVID-19–related symptoms cough, fever, dysgeusia, and diarrhea, as well as hospitalization in the index case-patient, in an additional linear mixed-effect logistic regression model, consisting only of households with a symptomatic index case-patient with known hospitalization status (n = 393) and adjusted for age of the index case-patient. The occurrences of fever and cough, but not of diarrhea, dysgeusia, or hospitalization, were significantly associated with a higher predicted SAR (Table 3).

Discussion

This large multicenter serologic SARS-CoV-2 household transmission study focusing on children revealed that the predicted SAR in household members <18 years of age is ≈8–13 percentage points lower than in adults. The predicted SAR also increased with increasing age of the index case-patient, which resulted in SARs of exposed household members ranging from 12.0% when the index case-patient was <12 years of age to 72.9% when the index case-patient was >60 years of age. The infectiousness of teenagers was similar to adults <60 years of age, and the predicted SAR was 31% in both groups.

Next to age, a systemic immune response after SARS-CoV-2 infection in the index case-patient, as indicated by circulating virus-specific antibodies, was strongly associated with the occurrence of secondary household cases. The biologic basis for the strikingly low SAR of 5.4% in households with a seronegative index case-patient (42/405) is unclear. Given the high specificity of SARS-CoV-2 RT-PCR testing, a proportion of 10% false-positive results is unlikely. Presumably, the individual viral load is associated with both a stronger adaptive immune response and the extent of symptoms, which in turn increase virus transmission. Our observations that fever and dysgeusia were less prevalent in seronegative index case-patients and that presence of fever and cough in the index case-patient increases SAR in exposed household members are in line with this hypothesis. Furthermore, our findings are in accordance with other studies, in which specific SARS-CoV-2 antibodies were frequently absent in patients with mild symptoms (15). However, the hypothesis that SARS-CoV-2 transmission is more likely in cases with higher or persisting viral load in the nasopharynx has not been formally tested.

Our observation of a SAR ≈10 percentage points higher in adults than in children is consistent with household studies based on RT-PCR–confirmed SARS-CoV-2 infection (10). In contrast, previous household transmission studies based on SARS-CoV-2 serologic testing reported lower (18), similar (28%) (17), or higher (43%–52%) (1921) SARs in children. However, these studies were relatively small.

A low proportion of pediatric index case-patients (6.2%) and an increasing SAR with increasing age of the index case-patient is in line with most previous serologic testing–based (24) or RT-PCR–based (10,13,25) household transmission studies comparing infectiousness of pediatric and adult index case-patients. In addition, Soriano-Arandes et al. (13) found fewer intrahousehold transmissions after reopening schools, whereas intraschool transmissions were rare events in several countries after schools reopened in 2020 (2632). Keeping schools open with strict hygiene measures in place could reduce overall SARS-CoV-2 transmission because close intrahousehold contact is reduced and children might act as sentinels for household transmissions when regularly tested at school.

Lower SARs in children have been previously attributed to differences in contact patterns; for example, physical interactions between spouses might be more intimate than between children and adults (33). Accordingly, we hypothesized that among children, toddlers might have more frequent and close physical contact with their parents than older children and adolescents, which might result in a SAR inversely correlated with age. However, we found the SAR to be similar among toddlers, older children, and adolescents, which indicates that behavior might not have a major effect on virus transmission within families. In contrast, the lower susceptibility to SARS-CoV-2 in children points toward the possible role of developmental factors related to host resistance and immunity. Low expression levels of angiotensin-converting enzyme 2, the cellular entry receptor of SARS-CoV-2 in the nasal epithelium of children has been previously suggested as a mechanistic factor (34). Moreover, previous endemic coronavirus infections in children might provide some protection, as indicated by frequently circulating cross-reacting antibodies (35) and SARS-CoV-2–reactive CD4+ T cells in <60% of unexposed children and adolescents (36). Furthermore, the innate immune response in children with SARS-CoV-2 exposure and infection might differ from that in adults, such as with respect to circulating neutrophil subsets, the induction of interferons (37), and cytokines (38).

The strengths of this study are its multicenter design, the high number of study participants, the application of robust statistical models, and a relatively low risk for recruitment bias, because potentially eligible households were invited through health authorities. Limitations are the high proportion of symptomatic index case-patients (97%) and adult (94%) index case-patients. Potential explanations are the limited diagnostic test capacities at the time of the study, which favored testing of symptomatic adults and those with work-related exposure (e.g., in the healthcare sector) or a history of travel to high-risk regions. In households with an asymptomatic index case-patient, symptomatic secondary case-patients were possibly mislabeled as index case-patients as a result of this testing policy. An overestimation of the SAR in adults and an underestimation in children is likely, because COVID-19-associated symptoms were a good predictor for SARS-CoV-2 infection in adults but not in children (16). COVID-19–related symptoms were not reported more frequently in seropositive children than seronegative children, and other respiratory viruses were >100 times more prevalent than SARS-CoV-2 in children with acute respiratory symptoms across Germany during February–May 2020 (39). Another factor that leads to an underestimation of the SAR is a negative SARS-CoV-2 IgG test result in <10% of previously infected participants, which might partly be because of false-negative test results and a physiologic reduction of SARS-CoV-2 IgG levels over time.

Other potential weaknesses of serologic testing–based household transmission studies are the difficulty of differentiating between secondary and tertiary transmission within the same household and the inability to rule out nonhousehold infections of exposed household members. This could result in an overestimation of the SAR per index case. The possibility that 1 nonhousehold (community) index case-patient infected several household members is a potential bias of this study. However, the probability of SARS-CoV-2 infections from 2 different nonhousehold (community) index case-patients can be assumed to be low, because this study was performed shortly after the first pandemic wave and the strict government-imposed lockdown (Appendix Figure), when the SARS-CoV-2 seroprevalence in southwest Germany was as low as 1.8% in adults and 0.6% in children (16). Finally, the findings regarding SAR and its age dependency only apply to the SARS-CoV-2 variants circulating in Germany at that time and might not be translated to the more transmissible Delta variant.

In conclusion, this multicenter SARS-CoV-2 household transmission study focusing on children demonstrates that secondary infections in household contacts generate a substantial disease burden. Age is a risk factor both for infectiousness of index cases and susceptibility of exposed household members. Furthermore, fever and cough in index case-patients were associated with higher levels of infectiousness. Households can be expected to remain sites for SARS-CoV-2 transmission because home quarantine and home isolation are key measures in cases of suspected or confirmed infections in most countries.

Dr. Stich is a resident at the Department of Pediatrics I, University Children’s Hospital Heidelberg, Germany. His research interests are viral diseases with a focus on human papillomavirus and SARS-CoV-2.

Top

Acknowledgments

We are especially indebted to all households who participated in this study. The engagement and great motivation of the participating recruiting physicians and nurses of the participating University Children’s Hospitals working 7 days per week to execute the study timely and quickly. Similarly, the staff in the 4 testing laboratories in Freiburg, Heidelberg, Tübingen, and Ulm require special recognition. We thank the staff of the following public health departments for their organizational support: Robin Schöttke (Alb-Donau); Sigrid Maassen (Breisgau-Hochschwarzwald); Andreas Welker, Rainer Schwertz (Heidelberg/Rhein-Neckar); Peter Friebel, Barbara Koch (Karlsruhe); Daniele Schutz, Nadja Oster, Katrin Schwöbel, Peter Schäfer (Mannheim); Martina Teinert, Lena Fuchs (Neckar-Odenwald); Gottfried Roller (Reutlingen); Martina Benzing, and Oliver Piehl (Tübingen). We thank the following persons for excellent organizational support: Julia Euler, Anette Ulbrich, Iris Schelletter, Heike Matzkuhn, Kristine Chobanyan-Jürgens (Heidelberg); Aileen Heselich, Alicia Zink, Tara Marianna Ziegelbauer, Bianca Rippberger, Simone Hock (Freiburg); Andrea Bevot, Sarah Johler (Tübingen); Sandra Steinmann, Boram Song, Eva-Maria Jacobsen (Ulm). We thank Dorothea Kronsteiner (Heidelberg), Martin Wolkewitz (Freiburg), and Rainer Muche (Ulm) for statistical consulting. We thank Florian Gleich (Heidelberg) for database assistance. We gratefully acknowledge Stefanie Wolf, Maria Anders-Össwein, Ira Pistorius-Knopf, and Markus Zorn (Heidelberg) for support in serological analyses. We thank Michael Schindler (Tübingen) for skillful assistance in conduction and interpretation of neutralization assays, Marlies Just (Ulm) for technical assistance, Ann-Kathrin Horlacher and Angelika Iftner (Tübingen) for support in serologic and RT-PCR analyses and Sigrid Enkel (Clinical Transfusion Medicine, Tübingen). We are grateful to the HILDA-Biobank, in particular Ali-Riza Kaya, and Marco Teller and Dirk Lebrecht at the FREEZE-Biobank (Freiburg). The work of Tim Waterboer was supported by a generous donation of the Dieter Morszeck Foundation.

The COVID-19 BaWü study was funded by the Ministry of Science, Research and the Arts Baden-Württemberg, Germany, within the framework of the special funding line for COVID-19 research, part of the measures to combat Coronavirus SARS-CoV-2 pandemic in the field of medical research. The funder of the study had no role in design or conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication.

Top

References

  1. Dong  E, Du  H, Gardner  L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect Dis. 2020;20:5334. DOIPubMedGoogle Scholar
  2. Zhou  F, Yu  T, Du  R, Fan  G, Liu  Y, Liu  Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:105462. DOIPubMedGoogle Scholar
  3. Dong  Y, Mo  X, Hu  Y, Qi  X, Jiang  F, Jiang  Z, et al. Epidemiology of COVID-19 among children in China. Pediatrics. 2020;145:e20200702. DOIPubMedGoogle Scholar
  4. Buonsenso  D, Roland  D, De Rose  C, Vásquez-Hoyos  P, Ramly  B, Chakakala-Chaziya  JN, et al. Schools closures during the COVID-19 pandemic: a catastrophic global situation. Pediatr Infect Dis J. 2021;40:e14650. DOIPubMedGoogle Scholar
  5. Lee  EC, Wada  NI, Grabowski  MK, Gurley  ES, Lessler  J. The engines of SARS-CoV-2 spread. Science. 2020;370:4067. DOIPubMedGoogle Scholar
  6. Viner  RM, Mytton  OT, Bonell  C, Melendez-Torres  GJ, Ward  J, Hudson  L, et al. Susceptibility to SARS-CoV-2 infection among children and adolescents compared with adults: a systematic review and meta-analysis. JAMA Pediatr. 2021;175:14356. DOIPubMedGoogle Scholar
  7. Spielberger  BD, Goerne  T, Geweniger  A, Henneke  P, Elling  R. Intra-household and close-contact SARS-CoV-2 transmission among children—a systematic review. Front Pediatr. 2021;9:613292. DOIPubMedGoogle Scholar
  8. Laxminarayan  R, Wahl  B, Dudala  SR, Gopal  K, Mohan B  C, Neelima  S, et al. Epidemiology and transmission dynamics of COVID-19 in two Indian states. Science. 2020;370:6917. DOIPubMedGoogle Scholar
  9. Park  YJ, Choe  YJ, Park  O, Park  SY, Kim  YM, Kim  J, et al.; COVID-19 National Emergency Response Center, Epidemiology and Case Management Team. Contact tracing during coronavirus disease outbreak, South Korea, 2020. Emerg Infect Dis. 2020;26:24658. DOIPubMedGoogle Scholar
  10. Madewell  ZJ, Yang  Y, Longini  IM Jr, Halloran  ME, Dean  NE. Household transmission of SARS-CoV-2: a systematic review and meta-analysis. JAMA Netw Open. 2020;3:e2031756. DOIPubMedGoogle Scholar
  11. Li  W, Zhang  B, Lu  J, Liu  S, Chang  Z, Peng  C, et al. Characteristics of household transmission of COVID-19. Clin Infect Dis. 2020;71:19436. DOIPubMedGoogle Scholar
  12. Wang  Y, Tian  H, Zhang  L, Zhang  M, Guo  D, Wu  W, et al. Reduction of secondary transmission of SARS-CoV-2 in households by face mask use, disinfection and social distancing: a cohort study in Beijing, China. BMJ Glob Health. 2020;5:e002794. DOIPubMedGoogle Scholar
  13. Soriano-Arandes  A, Gatell  A, Serrano  P, Biosca  M, Campillo  F, Capdevila  R, et al. COPEDI-CAT research group. Household SARS-CoV-2 transmission and children: a network prospective study. Clin Infect Dis. 2021; []. DOIGoogle Scholar
  14. Bi  Q, Wu  Y, Mei  S, Ye  C, Zou  X, Zhang  Z, et al. Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study. Lancet Infect Dis. 2020;20:9119. DOIPubMedGoogle Scholar
  15. Gudbjartsson  DF, Norddahl  GL, Melsted  P, Gunnarsdottir  K, Holm  H, Eythorsson  E, et al. Humoral immune response to SARS-CoV-2 in Iceland. N Engl J Med. 2020;383:172434. DOIPubMedGoogle Scholar
  16. Tönshoff  B, Müller  B, Elling  R, Renk  H, Meissner  P, Hengel  H, et al. Prevalence of SARS-CoV-2 infection in children and their parents in southwest Germany. JAMA Pediatr. 2021;175:58693. DOIPubMedGoogle Scholar
  17. Laws  RL, Chancey  RJ, Rabold  EM, Chu  VT, Lewis  NM, Fajans  M, et al. Symptoms and transmission of SARS-CoV-2 among children—Utah and Wisconsin, March–May 2020. Pediatrics. 2021;147:e2020027268. DOIPubMedGoogle Scholar
  18. Dattner  I, Goldberg  Y, Katriel  G, Yaari  R, Gal  N, Miron  Y, et al. The role of children in the spread of COVID-19: Using household data from Bnei Brak, Israel, to estimate the relative susceptibility and infectivity of children. PLOS Comput Biol. 2021;17:e1008559. DOIPubMedGoogle Scholar
  19. Lewis  NM, Chu  VT, Ye  D, Conners  EE, Gharpure  R, Laws  RL, et al. Household transmission of SARS-CoV-2 in the United States. . Clin Infect Dis. 2020.

  20. Ladhani  SN, Andrews  N, Aiano  F, Baawuah  F, Amin-Chowdhury  Z, Brown  KE, et al. Secondary attack rate and family clustering of SARS-CoV-2 infection in children of healthcare workers with confirmed COVID-19. Clin Infect Dis. 2021;73:e2603. DOIPubMedGoogle Scholar
  21. Buonsenso  D, Valentini  P, De Rose  C, Pata  D, Sinatti  D, Speziale  D, et al.; Gemelli Against COVID-19 Post-Acute Care Study Group. Seroprevalence of anti-SARS-CoV-2 IgG antibodies in children with household exposure to adults with COVID-19: Preliminary findings. Pediatr Pulmonol. 2021;56:13747. DOIPubMedGoogle Scholar
  22. Ruetalo  N, Businger  R, Althaus  K, Fink  S, Ruoff  F, Pogoda  M, et al. Antibody response against SARS-CoV-2 and seasonal coronaviruses in nonhospitalized COVID-19 patients. MSphere. 2021;6:e0114520. DOIPubMedGoogle Scholar
  23. Fokkema  M, Smits  N, Zeileis  A, Hothorn  T, Kelderman  H. Detecting treatment-subgroup interactions in clustered data with generalized linear mixed-effects model trees. Behav Res Methods. 2018;50:201634. DOIPubMedGoogle Scholar
  24. Galow  L, Haag  L, Kahre  E, Blankenburg  J, Dalpke  AH, Lück  C, et al. Lower household transmission rates of SARS-CoV-2 from children compared to adults. J Infect. 2021;83:e346. DOIPubMedGoogle Scholar
  25. Thompson  HA, Mousa  A, Dighe  A, Fu  H, Arnedo-Pena  A, Barrett  P, et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) setting-specific transmission rates: a systematic review and meta-analysis. Clin Infect Dis. 2021;73:e75464. DOIPubMedGoogle Scholar
  26. Buonsenso  D, De Rose  C, Moroni  R, Valentini  P. SARS-CoV-2 infections in Italian schools: preliminary findings after 1 month of school opening during the second wave of the pandemic. Front Pediatr. 2021;8:615894. DOIPubMedGoogle Scholar
  27. Ismail  SA, Saliba  V, Lopez Bernal  J, Ramsay  ME, Ladhani  SN. SARS-CoV-2 infection and transmission in educational settings: a prospective, cross-sectional analysis of infection clusters and outbreaks in England. Lancet Infect Dis. 2021;21:34453. DOIPubMedGoogle Scholar
  28. Zimmerman  KO, Akinboyo  IC, Brookhart  MA, Boutzoukas  AE, McGann  KA, Smith  MJ, et al.; ABC SCIENCE COLLABORATIVE. Incidence and secondary transmission of SARS-CoV-2 infections in schools. Pediatrics. 2021;147:e2020048090. DOIPubMedGoogle Scholar
  29. Yung  CF, Kam  KQ, Nadua  KD, Chong  CY, Tan  NWH, Li  J, et al. Novel coronavirus 2019 transmission risk in educational settings. Clin Infect Dis. 2021;72:10558. DOIPubMedGoogle Scholar
  30. Macartney  K, Quinn  HE, Pillsbury  AJ, Koirala  A, Deng  L, Winkler  N, et al.; NSW COVID-19 Schools Study Team. Transmission of SARS-CoV-2 in Australian educational settings: a prospective cohort study. Lancet Child Adolesc Health. 2020;4:80716. DOIPubMedGoogle Scholar
  31. Otte Im Kampe  E, Lehfeld  AS, Buda  S, Buchholz  U, Haas  W. Surveillance of COVID-19 school outbreaks, Germany, March to August 2020. Euro Surveill. 2020;25:2001645. DOIPubMedGoogle Scholar
  32. Ehrhardt  J, Ekinci  A, Krehl  H, Meincke  M, Finci  I, Klein  J, et al. Transmission of SARS-CoV-2 in children aged 0 to 19 years in childcare facilities and schools after their reopening in May 2020, Baden-Württemberg, Germany. Euro Surveill. 2020;25:25. DOIPubMedGoogle Scholar
  33. Goldstein  E, Lipsitch  M, Cevik  M. On the effect of age on the transmission of SARS-CoV-2 in households, schools, and the community. J Infect Dis. 2021;223:3629. DOIPubMedGoogle Scholar
  34. Bunyavanich  S, Do  A, Vicencio  A. Nasal gene expression of angiotensin-converting enzyme 2 in children and adults. JAMA. 2020;323:24279. DOIPubMedGoogle Scholar
  35. Ng  KW, Faulkner  N, Cornish  GH, Rosa  A, Harvey  R, Hussain  S, et al. Preexisting and de novo humoral immunity to SARS-CoV-2 in humans. Science. 2020;370:133943. DOIPubMedGoogle Scholar
  36. Grifoni  A, Weiskopf  D, Ramirez  SI, Mateus  J, Dan  JM, Moderbacher  CR, et al. Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals. Cell. 2020;181:14891501.e15. DOIPubMedGoogle Scholar
  37. Neeland  MR, Bannister  S, Clifford  V, Dohle  K, Mulholland  K, Sutton  P, et al. Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children. Nat Commun. 2021;12:1084. DOIPubMedGoogle Scholar
  38. Buonsenso  D, Sali  M, Pata  D, De Rose  C, Sanguinetti  M, Valentini  P, et al. Children and COVID-19: Microbiological and immunological insights. Pediatr Pulmonol. 2020;55:254755. DOIPubMedGoogle Scholar
  39. Oh  DY, Buda  S, Biere  B, Reiche  J, Schlosser  F, Duwe  S, et al. Trends in respiratory virus circulation following COVID-19-targeted nonpharmaceutical interventions in Germany, January – September 2020: Analysis of national surveillance data. Lancet Reg Health Eur. 2021;6:100112. DOIPubMedGoogle Scholar

Top

Figures
Tables

Top

Suggested citation for this article: Stich M, Elling R, Renk H, Janda A, Garbade SF, Müller B, et al. Transmission of severe acute respiratory syndrome coronavirus 2 in households with children, southwest Germany, May–August 2020. Emerg Infect Dis. 2021 Dec [date cited]. https://doi.org/10.3201/eid2712.210978

DOI: 10.3201/eid2712.210978

Original Publication Date: October 25, 2021

Table of Contents – Volume 27, Number 12—December 2021

Top

Page created: September 16, 2021

Page updated: October 25, 2021

Page reviewed: October 25, 2021

The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors’ affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.

Source : CDC Emerging Infectious Diseases Journal

NBS Bank Your Caring Bank

Continue Reading

News

Africa must close its science and technology gap to take full advantage of the AfCFTA says Ameenah Gurib-Fakim at Afreximbank’s fifth annual Babacar Ndiaye Lecture – The Maravi Post

Published

on

By


CAIRO, Egypt, 25 October 2021-/African Media Agency (AMA)/- H.E. Professor Ameenah Gurib-Fakim, the former President of Mauritius and Laureate of the 2007 L’Oréal-UNESCO Prize for Women in Science, delivered a trenchant address at the African Export-Import Bank’s (Afreximbank) fifth annual Babacar Ndiaye Lecture on “the importance of science, technology and innovation in the transformation of African economies”. She called on African leaders to close the region’s science and technology gap to take full advantage of the African Continental Free Trade Area (AfCFTA).

H.E. Professor Ameenah Gurib-Fakim,
Former President of Mauritius and Laureate of the 2007 L’Oréal-UNESCO Prize for Women in Science

Professor Gurib-Fakim, delivered the keynote speech at the Bank’s annual flagship event and laid bare a raft of statistics that showed that Africa is falling well behind the rest of the world in science, technology, and innovation (STI). Only 0.1% of all patent applications are registered in Africa, compared to 65% in Asia and 25% in North America. Africa is also responsible for only 2% of the world’s research output and 1% of research spending. Furthermore, the laggards in Africa have 11 researchers per million people whilst the best performing countries in the world, such as South Korea and Denmark had between 7,000-8,000 scientists and researchers per million people.

“How can a continent with the largest share of arable land, a continent with the youngest population, a continent that has fueled all of the world’s industrial revolution, a continent that has helped drive the mobile phone industry, a continent that is at the cusp of supporting the world’s energy transition to greener technology with a large store of rare earth deposits accept such dismal statistics?” she asked. 

Watch the full replay of the event 

She blamed “chronic neglect”, the statistics demonstrating that the chronic deficit of researchers and scientists has undoubtedly contributed to the poverty trap that the continent finds itself in. “The deficit of investment in science and technology and absence of economic and scientific infrastructure has undermined the process of economic transformation both at the structural level and at the sectoral level. The consequences of that deficit have been significant and include continued reliance on the colonial model of resource extraction largely responsible for the debilitating poverty trap and aid dependence trap.”

The former President remarked that Africa’s failure to advance in science and technology has been compounded by the fragmentation of its markets. She praised the establishment of AfCFTA for overcoming this hurdle and creating the largest single market in the world by membership. However, the economic transformation anticipated by the free-trade market hinges on Africa “closing its scientific and technological gap with the rest of the world” and “sustainably producing the right set of skills to expand both extra and intra African trade.”

This will require collaboration and partnerships to create the right conditions to develop centres of excellence on the continent. Academia, governments and the private sector, she argued, would have to collaborate much more closely to ensure the funding is provided and that the conditions for science to thrive are put in place. In this regard, she praised the leadership role played by Afreximbank in the medical field where the Bank is supporting the growth of pharmaceutical industries and establishment of medical center of excellence.

Professor Gurib-Fakim reminded the audience that the increasing role of technology that was permeating all sectors and industries and driving growth was irreversible. She praised Africa’s successes in certain areas like mobile money, giving the example of M-Pesa which has been adopted in the rest of Africa after being created in Kenya. She equally praised Afreximbank’s Pan-African Payment and Settlement System (PAPSS) which is set to facilitate payments for cross-border trade in African currencies and assuage the liquidity constraints.

One of the major challenges, she said, is the continued brain drain of Africa’s brightest and best scientific minds. The former President encouraged the private and public sector to invest much more in education and research and development. “Every young African has the potential to be a great scientist, to innovate and become globally competitive,” she said.

Professor Benedict Oramah, the President and Chairman of the Board of Directors of Afreximbank, introduced the lecture by observing that although Africa gained independence six decades ago it has nonetheless failed to achieve economic emancipation. Professor Oramah said that the failure of Africa to secure Covid-19-related equipment such as face masks and ventilators shows that the continent must start manufacturing its own technological goods.

The President of the Bank further pointed out that “while the AfCFTA was a necessary condition for the transformation of African economies, it was not a sufficient one, especially in a world where trade has been largely driven by manufactured goods with increasing technological content.” Among the set of constraints undermining the capacity of the AfCFTA to deliver on its full potential none was as critical as closing the region’s scientific and technological gap. He said: “The most competitive countries in the world are also the ones leading in ICT, innovation, scientific research and development. Africa cannot be kept at the back of the queue.” He also stressed the need to foster the collaboration between research and industry to further enhance the growth and development impact of scientific discovery across the region.

The President of the Bank remarked that Africa once boasted some of the most wealthy and industrious city-states and kingdoms – something that has been forgotten by the rest of the world. He quoted the Portuguese explorer Pedro Alvares Cabral who in the 1500s landed on the coast of Tanzania and found a land full of rich merchants. He also referenced Lourenco Pinto, a Portuguese merchant, who noted that the capital city of the Kingdom of Benin, in modern day Nigeria, was larger than Lisbon and both industrious and wealthy.

Professor Sarah Anyang Agbor, Commissioner of Human Resources, Science and Technology at the African Union Commission (AUC), spoke about continental plans to boost science and technology in Africa. The AUC has set in place its Science, Technology, and Innovation Strategy for Africa 2024 (STISA-2024) that aims to promote the building and upgrading of research institutions, amongst other things. The plan fits within the African Union’s (AU) Agenda 2063, she said.

Dr Hippolyte Fofack, Afreximbank’s Chief Economist, wrapped up the event by echoing Professor Oramah’s statements that “Africa was the epicentre of and the birthplace of astronomy and mathematics”. He referenced the Dogon community in Mali who for centuries has been fully aware of an invisible star, Sirius B, long before it was discovered by Western astronomers in 1970. “Africa’s current scientific and technological gap with the rest of the world was a historical anomaly”, he added.

However, Dr Hippolyte Fofack welcomed ongoing efforts (though still marginal) by both public and private institutions to mainstream science and technology across the region. He added that Afreximbank has long championed technology and innovation as important drivers of Africa’s economic growth and structural transformation, convinced that setting Africa back on the path of scientific renaissance was a sine qua none condition for economic renaissance and structural transformation.

Lebo Mashile, a South African poet and writer, opened the lecture with a grand and evocative poem that touched on various themes of African history and the continent’s interaction with the rest of the world. Answering the fundamental question who are we? She said “being African is applied science of humanity.” There was also an uplifting musical performance by Cameroonian artiste, Joyce Babatunde.

The Babacar Ndiaye Lecture series, launched by Afreximbank five years ago, honours the founding role Dr Babacar Ndiaye played in the establishment of Afreximbank. As President of the African Development Bank from May 1985 to August 1995, he is credited with championing the establishment of several major continental institutions to drive the process of economic growth and structural transformation of African economies. 

Distributed by African Media Agency (AMA) on behalf of AfreximBank.

About Afreximbank:

African Export-Import Bank (Afreximbank) is a Pan-African multilateral financial institution mandated to finance and promote intra-and extra-African trade. Afreximbank deploys innovative structures to deliver financing solutions that support the transformation of the structure of Africa’s trade, accelerating industrialization and intra-regional trade, thereby boosting economic expansion in Africa. The Bank has a rich history of intervening in support of African countries in times of crisis. Through the Pandemic Trade Impact Mitigation Facility (PATIMFA) launched in April 2020, Afreximbank has disbursed more than US$10 billion since the outbreak of the pandemic to help member countries manage the adverse impact of financial, economic, and health shocks caused by the COVID-19 pandemic. A stalwart supporter of the African Continental Free Trade Agreement (AfCFTA), Afreximbank has completed the development of a Pan-African Payment and Settlement System (PAPSS) that was adopted by the African Union (AU) as the payment and settlement platform to underpin the implementation of the AfCFTA. Afreximbank is working with the AU and the AfCFTA Secretariat to develop an Adjustment Facility to support countries in effectively participating in the AfCFTA. At the end of 2020, the Bank’s total assets and guarantees stood at US$21.5 billion, and its shareholder funds amounted to US$3.4 billion. Afreximbank disbursed more than US$42 billion between 2016 and 2020. The Bank has ratings assigned by GCR (international scale) (A-), Moody’s (Baa1) and Fitch (BBB-). The Bank is headquartered in Cairo, Egypt.

For more information, visit: www.afreximbank.com.
Media Contact: Amadou Labba Sall, asall@afreximbank.com

Source : African Media Agency (AMA)

Continue Reading

News

Libya election candidacy bids to open in November – The Maravi Post

Published

on

By


The head of Libya’s election commission Emad Al-Shadly Al-Sayah said Sunday that the commission will open registration for the presidential and parliamentary candidates in November.

During in a news conference held in the capital Tripoli, Al-Sayah announced that the registration process will start by mid-November when technical and logistical preparations are completed.

The elections are a major step forward in efforts to end the decade-old violence by forming a new political leadership with widespread legitimacy.

The chairman also announced a “proactive process” will be launched from Monday, which includes publishing a list of the names of people registered to vote, to ensure transparency and “allow the concerned to challenge the names contained in them.”

Al-Sayah added that forms of the endorsement lists, stipulated by the electoral laws on the candidates for the presidential and parliamentary elections, will be published on the Commission’s website on Sunday.

“The acceptance of candidacy for the presidential and parliamentary elections will be available upon completion of the necessary technical and logistical preparations for this stage,” he added.

On Thursday, the Libyan Prime Minister, Abdel Hamid Dbeibah, and a number of foreign powers approved holding general elections on December 24, as stated in a U.N.-backed peace plan aimed at ending the turmoil and divisions that have plagued the country for years.

Although Libya’s parliament passed a law on presidential elections on that date, it also passed a separate law providing for the organization of parliamentary elections at a later date.

Other political institutions in Libya rejected the parliament’s proposals.

The first round of presidential elections is scheduled for December 24, with Al-Sayah announcing that a second round will be held at a later date, in addition to the parliamentary elections.

Source: Africanews

Continue Reading

Trending

Copyright © 2020 PRUMETRICS