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South African biotech company says work is in progress for messenger RNA jab – The Maravi Post



South African biotech consortium is working on a messenger RNA jab based on the Moderna formula in a ground-breaking drive to end Africa’s life-threatening lack of Covid vaccines.

Cape Town-based Afrigen Biologics and Vaccines is leading a pilot project, backed by the UN’s World Health Organization (WHO) and the COVAX initiative, which seeks to tweak Moderna’s revolutionary drug.

The goal is an mRNA vaccine that suits poorer countries in hot climates.

It would be a tough, resilient vaccine that would not need to be stored all the time at ultra-cold temperatures — a hefty requirement in places where power cuts are a problem.

Africa is the least vaccinated continent in the world.

More than 10 months after the world’s first Covid shot was administered and nearly two years into the pandemic itself, barely five percent of eligible Africans have been fully immunised.

The problem has exposed Africa’s huge dependence on imported vaccines and its tech weakness compared with Europe, China and the United States.

“The bitter lesson we’ve learnt throughout this pandemic is how Africa was almost 100-percent dependent” on vaccines produced outside the continent, Richard Mihigo, the WHO’s vaccination coordinator in Africa, told AFP.

Research and development at a 130-million-rand ($8.7-million) facility started three months ago, and talks are underway Moderna for a licensing agreement to use the basic formula.

– Tests within a year? –

Twenty-two scientists are working on the huge challenges.

The idea is to have a “super efficient and safe (vaccine that) … will have a different stability and more suitable to be distributed at a temperature which is feasible for Africa,” said Afrigen’s managing director, Petro Terreblanche.

“It will be developed for maximum protection of the variants that is relevant for the territories where variants are rapidly surfacing,” she added.

“What we are looking for is to have a second-generation vaccine,” said Martin Friede of the WHO’s Initiative for Vaccine Research.

“We have to start with a Moderna look-alike and be as close to Moderna as we can get,” he said.

“It’s not a copy of Moderna.”

If all goes to plan, prototype shots will be ready for clinical trials within a year.

If those tests show that the modified jab is safe and effective, vaccine producer Biovac, a neighbour to Afrigen, will be the first to produce it on a commercial scale.

After that Afrigen will train other countries and hand out production licences to poor nations left out in the race for the life-saving shots.

– Patent question –

The Medicines Patent Pool, an international organisation that works to facilitate the development of medicines for low- and middle-income countries, is leading negotiations with Moderna.

Hopefully “we might get from them an agreement not to enforce any of their patents,” Charles Gore, the organisation’s boss, said in Geneva last month.

The Afrigen team say they are “reverse-engineering” the vaccine in a first step to see how it works.

“This is considered R and D (research and development), so there isn’t any infringement of intellectual property and in the process we learn how you make mRNA, to be able to produce it at a scale that would be useful for clinical trials,” said Afrigen’s technical director Caryn Fenner.

Pharma giants are facing huge pressure to ease patent controls over coronavirus vaccines to help production in regions scrambling for shots.

Moderna last week announced plans to build a state-of-the-art mRNA facility in Africa to churn out up to 500 million vaccines doses anually.

It did not state where the factory will be stationed nor the initiation date.

The Afrigen project is funded via the COVAX initiative, which aims to facilitate equitable access to vaccines worldwide.

It is the latest vaccine investment in South Africa this year — the country on the continent most affected by the pandemic.

Johnson & Johnson has an operational “fill-and-finish” plant in South Africa, and Pfizer/BioNTech have partnered with Biovac to bottle their mRNA vaccine starting next year.

Biotech billionaire Patrick Soon-Shiong is also planning to start transferring technology to begin vaccine production in 2022.

Elsewhere on the continent, several Covid vaccine production facilities are in the pipeline, including in Algeria, Egypt, Morocco, Nigeria, Rwanda to Senegal.

“Africa needs to become over the next 20 years autonomous in vaccine production,” said Friede.

“This needs to be done, full stop.”

Source: Africanews

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Kim Seon Ho Will Leave the Show After the Scandal




Here is breaking news that will make you curious to know the full coverage. As you know very well that the show ‘2 days 1 Night’ is getting such huge attention in the past few days. There are many people who are excited to know the current latest news. So here we going to tell you about Kim Seon Ho news who left the show and his position in the show. So let begin our article and get all the information now.

kim seon ho

As per the news, Kim Seon Ho has withdrawn from his position as a fixed member of 2 days 1 Night show. Along with it, we got the news that the production team of this show has held a meeting earlier on October 20 KST. The meeting was held regarding his departure. Now definitely you have various questions in your mind and it is normal. So we want to tell you that reportedly we found that he expressed his own intention to leave the program. It was a big sign that he will leave this how very soon and now the news about the matter is here among all of us.

The news of Kim Seon Ho’s withdrawal from the cast has already been relayed to the other fixed casts members — Yeon Jung Hoon, Moon Se Yoon, DinDin, Kim Jong Min, and Ravi.

This is a very popular show and famous because of its thriller tasks in the show. Most probably now the show may have some problems and getting fall in the TRP because one of the entertaining contestants has left the show. So far here is the various audience who continuously watched the show and probably they will continue to watch the show. According to the news, both the production house and Ho have apologized for the scandal. It has confused many viewers and many viewers are troubled because of this. If you have any queries regarding the show then you can ask us in the comment section. We will definitely tell you brief information. For further information stay with us and get all the details on time.

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Welcome to Raccoon City Preview Release Date & Time Revealed




One of the most popular and famous running movie sequels of Resident Evil has been capturing a massive fan following across the world because of its amazing story and concept. The sequel of the movie has been running for the last many years and now, the makers are coming with another one. Sony Pictures has released the new poster for the action, horror, and thriller movie Resident Evil: Welcome to Raccoon City. Since the poster was released, the excitement among the fans can be seen increasing and it is capturing big attention among fans. There are lots of big actors becoming a part of the movie and like always, you will be amazed to watch the next reboot.

Resident Evil

The movie is featuring Kaya Scodelario as Claire Redfield, Hannah John-Kamen as Jill Valentine, Robbie Amell as Chris Redfield, Tom Hopper as Albert Wesker, Avan Jogia as Leon S. Kennedy, Donal Logue as Chief Brian Irons, Neal McDonough as Williams Birkin, Lily Gao as Ada Wong, and Chad Rock as Richard Aiken. These actors and actresses are going to be a part of the movie and play crucial roles to expose Umbrella Corporation.

The movie is directed and written by Johannes Roberts which is based on Resident Evil by Capcom. James Harris, Hartley Gorenstein, and Robert Kulzer are the producers and it is produced under the banner of Screen Gems, The Fyzz Facility, Constantin Film, The Tea Shop, and Film Company, and David Films. Again, the fans of Resident Evil will get to see some different types of action, horror, and thriller.

Maybe, the makers are not going to stop directing the sequel of the movie and they have launched a back-to-back sequel of the movie. Resident Evil (Film) was first launched in 2002 and then, Resident Evil: Apocalypse launched in 2004. Since then, the makers have released four more parts of Resident Evil and now, the 7th one will release in theatres across the world. If you are eagerly waiting to watch this movie on theatres so, the Sony Picture has scheduled to release of the movie and the movie will hit the theatre’s screens on November 24, 2021, in the United States.

This time, the movie is going to hit a different level as Raccoon City is now a dying Midwestern Town. The company has left the city a wasteland but the big evils are brewing on the land of Raccoon City. When the evil will cross its line, a group of survivors works together to uncover the hidden reality behind Umbrella Corporation. There is no doubt that the movie will have lots of action and horror.

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What Is Bones Or No Bones Day On TikTok? Noodle Pug Viral Memes Videos Trend On Social Media




The renowned Video Sharing Platform TikTok is remaining the subject of discussion among the users, as they are becoming the witness of several trends. Recently, TikTok is consulting and aging pug to see if it’s a “Bones or No Bones Day”. So now the entire attention has been grabbed by the trend because several users are keen to get the comprehensive details about it, because it is trending on the app and attracting their attention towards it. So below you can get all crucial details regarding the trend along with the reason behind it.

What Is 'Bones Or No Bones Day' On TikTok

As per the exclusive reports, a 13-years-old pug who is appearing in the video is creating a buzz on social media, ever since his owner, Jonathan Graziano shared a glimpse by mentioning “Have you or a loved used “It’s a no-bones day as an explanation to get out of something yet”. Ever since, it converted into the trend it brought the bunches of the question as well. This indicates the curiosity of the users who wants to know the comprehensive reason behind the story, of trending because whenever something gets heated on social media so users would like to be acquainted themselves with entire details.

Bones Or No Bones Day Memes

As everyone knows that TikTok is the only video-sharing platform where anything could viral in less time than other sites, and it also counts on the top when it comes to watching trending videos. Each day brings fresh trends which becomes the subject of discussion among all those who use the app for sharing their entertaining videos. If the sources are to be believed, so it became the turning point of several users life, who got popularity and their career got the new heights as well, but the latest trend of Elderly Pug so it is not clear what is the story behind it.

Ever since His video became massively popular uncounted users visited his profile to check the details that “what kind of day it will be for them”. No bones are getting popular more as it is giving the users secondhand permission to noodles out. Massive reactions have hit the bricks as well where users are addressing pug so cute, so here we have mentioned such details which have been delivered by the sources. Hence, whenever more would arrive we will make you familiar with that for sure, so stay connected with us.

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